Pearl of Great Price may refer to:

• Parable of the Pearl, a parable told by Jesus in explaining the value of the Kingdom of Heaven
• Pearl (poem), a Middle English alliterative poem written in the late 14th century
• Pearl of Great Price (Latter Day Saints), part of the standard works of The Church of Jesus Christ of Latter-day Saints
• Pearl of Great Price (album), 1991 album by industrial music band Will